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In the present work, twelve N-substituted 2- 5-nitro-thiophene -thiosemicarbazones derivatives L were synthesized, characterized and their in vitro cytotoxic and antifungal activities were evaluated against Candida sp. The probable mechanisms of action have been investigated by sorbitol and ergosterol assays.

Additionally, ultrastructural study by Scanning Electron Microscopy was performed with the L10 compound. The results showed that all strains were more sensitive to the compound L10 except Candida tropicalis URM Concerning the study of the possible mechanism of action, the compounds were not able to bind to ergosterol in the membrane, do not act by inhibiting the synthesis of fungal cell wall sorbitol assay.

However, the Scanning Electron Microscopy - SEM analysis shows significant morphological changes in shape, size, number of cells and hyphae, and cell wall indicating a possible mechanism of action by inhibition of enzymes related to the ergosterol biosynthesis pathway.

Our results demonstrate that N-substituted 2- 5-nitro-thiophene -thiosemicarbazones derivatives are potential antifungal agents with activity associated with inhibition of enzymes related to biosynthesis of ergosterol. This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

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Similar articles Identification and characterization of thiosemicarbazones with antifungal and antitumor effects: cellular iron chelation mediating cytotoxic activity. Chem Res Toxicol. Epub Aug PMID: Synthesis and biological evaluation of new naphthalene substituted thiosemicarbazone derivatives as potent antifungal and anticancer agents.

Eur J Med Chem. Epub Nov In vitro cytotoxic, antibacterial, antifungal and urease inhibitory activities of some N4- substituted isatinthiosemicarbazones. Pervez H, et al. J Enzyme Inhib Med Chem. Synthetic arylquinuclidine derivatives exhibit antifungal activity against Candida albicans, Candida tropicalis and Candida parapsilopsis.

Ishida K, et al. Ann Clin Microbiol Antimicrob. Show more similar articles See all similar articles. Dierickx P, et al. Epub May MeSH terms Animals Actions. Magnetic Resonance Spectroscopy Actions. Mass Spectrometry Actions. Mice Actions. Microbial Sensitivity Tests Actions. Microscopy, Electron, Scanning Actions.

Substances Antifungal Agents Actions. Thiosemicarbazones Actions. Full-text links [x] Elsevier Science. Copy Download.

CUIDADOS DE ENFERMERIA EN TANATOLOGIA PDF

Synthesis, Cytotoxicity and Antifungal Activity of 5-nitro-thiophene-thiosemicarbazones Derivatives

In the present work, twelve N-substituted 2- 5-nitro-thiophene -thiosemicarbazones derivatives L were synthesized, characterized and their in vitro cytotoxic and antifungal activities were evaluated against Candida sp. The probable mechanisms of action have been investigated by sorbitol and ergosterol assays. Additionally, ultrastructural study by Scanning Electron Microscopy was performed with the L10 compound. The results showed that all strains were more sensitive to the compound L10 except Candida tropicalis URM Concerning the study of the possible mechanism of action, the compounds were not able to bind to ergosterol in the membrane, do not act by inhibiting the synthesis of fungal cell wall sorbitol assay.

CISCO WS-C3750G-12S-S DATASHEET PDF

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