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Colinergic system: revisiting receptors, regulation and the relationship with Alzheimer disease, schizophrenia, epilepsy and smoking. Ana L. Ventura I ; Paula A. Castro II. The protein G coupled receptors dessensibilization and internalization mediated by kinases have been described in proliferation, differentiation and cell death, and also in neurologic disorders.

The data produced so far may help on planning medicaments more specific for these pathologies treatment. Keywords: Receptors, cholinergic, Alzheimer disease, schizophrenia, epilepsy, smoking. Em , Barlow et al. Wang et al. Goodman et al. Bruneau EG, Akaaboune M. Running to stand still: ionotropic receptor dynamics at central and peripheral synapses. Mol Neurobiol. Basic and clinical aspects of non-neuronal acetylcholine: expression of an independent, non-neuronal cholinergic system in lymphocytes and its clinical significance in immunotherapy.

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G protein-coupled receptors: heterologous regulation of homologous desensitization and its implications. Reinera C, Nathanson NM. The internalization of the M2 and M4 muscarinic acetylcholine receptors involves distinct subsets of small G-proteins. Life Sci. Localization of the arrestin binding locus to the clathrin terminal domain. Intraneuronal trafficking of G-protein-coupled receptors in vivo. Trends Neurosci. Cummings JL, Back C. The cholinergic hypothesis of neuropsychiatric symptons in alzheimer disease.

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