BLOQUEANTES COLINERGICOS PDF

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Colinergic system: revisiting receptors, regulation and the relationship with Alzheimer disease, schizophrenia, epilepsy and smoking. Ana L. Ventura I ; Paula A. Castro II. The protein G coupled receptors dessensibilization and internalization mediated by kinases have been described in proliferation, differentiation and cell death, and also in neurologic disorders.

The data produced so far may help on planning medicaments more specific for these pathologies treatment. Keywords: Receptors, cholinergic, Alzheimer disease, schizophrenia, epilepsy, smoking. Em , Barlow et al. Wang et al. Goodman et al. Bruneau EG, Akaaboune M. Running to stand still: ionotropic receptor dynamics at central and peripheral synapses. Mol Neurobiol. Basic and clinical aspects of non-neuronal acetylcholine: expression of an independent, non-neuronal cholinergic system in lymphocytes and its clinical significance in immunotherapy.

J Pharmacol Sci. Taylor P, Brown JH. Nicotinic receptors. Basic neurochemistry: molecular, cellular, and medical aspects Philadelphia : Raven Press; Sensitivity of young rats to nicotine exposure: Physiological and biochemical parameters. Ecotoxicol Environ Saf. Dale HH. The action of certain esters and ethers of choline, and their relation to muscarine. J Pharmacol Exp Ther. J Neurochem. Millar NS, Gotti C. Diversity of vertebrate nicotinic acetylcholine receptors. Nicotinic receptor function in the mammalian central nervous system.

Ann NY Acad Sci. Wang H, Sun X. Desensitized nicotinic receptors in brain. Brain Res Brain Res Rev. Brain Res Mol Brain Res. Regulation of human alpha4beta2 neuronal nicotinic acetylcholine receptors by cholinergic channel ligands and second messenger pathways.

Mol Pharmacol. Desensitization of neuronal nicotinic receptors, J Neurobiol. Mammalian nicotinic acetylcholine receptors: from structure to function. Physiol Rev. The clinical impact of pharmacogenetics on the treatment of epilepsy.

Green fluorescent protein-labeled mapping of neural stem cells migrating towards damaged areas in the adult central nervous system. Cell Biol Int. Muscarinic acetylcholine receptors as CNS drug targets.

Pharmacol Ther. The pharmacology of flaxedil with observations on certain analogs. Ann Ny Acad Sci. A comparison of affinity constants for muscarine-sensitive acetylcholine receptors in guinea-pig atrial pacemaker cells at 29 degrees C and in ileum at 29 degrees C and 37 degrees C.

Br J Pharmacol. The cysteine residue in the carboxyl-terminal domain of the M2 muscarinic acetylcholine receptor is not required for receptor-mediated inhibition of adenylate cyclase. Wess J. Molecular basis of muscarinic acetylcholine receptor function. Trends Pharmacol Sci. Sandiford S, Slepak V.

Caulfield MP. Muscarinic receptors-characterization, coupling and function. Localization of muscarinic M3 receptor protein and M3 receptor binding in rat brain. Hamilton E, Nathanson NM. The M1 receptor is required for muscarinic activation of mitogen-activated protein MAP kinase in murine cerebral cortical neurons.

J Biol Chem. Identification and localization of muscarinic acetylcholine receptor proteins in brain with subtype-specific antibodies. J Neurosci. Coupling of M2 muscarinic receptors to membrane ion channels via phosphoinositide 3-kinase gamma and atypical protein kinase C. M1, M3 and M5 muscarinic receptors stimulate mitogen-activated protein kinase.

Kimura F, Baughman RW. Distinct muscarinic receptor subtypes suppress excitatory and inhibitory synaptic responses in cortical neurons. J Neurophysiol. Eur J Pharmacol. The role of receptor kinases and arrestins in G protein-coupled receptor regulation. Annu Rev Pharmacol Toxicol. Scarselli M, Donaldson JG. Constitutive internalization of G protein-coupled receptors and G proteins via clathrin-independent endocytosis.

G protein-coupled receptors: heterologous regulation of homologous desensitization and its implications. Reinera C, Nathanson NM. The internalization of the M2 and M4 muscarinic acetylcholine receptors involves distinct subsets of small G-proteins. Life Sci. Localization of the arrestin binding locus to the clathrin terminal domain. Intraneuronal trafficking of G-protein-coupled receptors in vivo. Trends Neurosci. Cummings JL, Back C. The cholinergic hypothesis of neuropsychiatric symptons in alzheimer disease.

Am J Geriatr Psychiatry. Multifunctional neuroprotective derivatives of rasagiline as anti-Alzheimers disease drugs. Alzheimer disease: current concepts and emerging diagnostic and therapeutic strategies.

Ann Intern Med. Characterization of nicotinic acetylcholine receptor-mediated [ 3 H]-dopamine release from rat cortex and striatum. Cellular mechanisms of nicotine addiction. Pharmacol Biochem Behav. Fiore MC. US public health service clinical practice guideline: treating tobacco use and dependence. Respir Care. Varenicline for smoking cessation: a placebo-controlled, randomized study.

Efficacy and safety of the novel selective nicotinic acetylcholine receptor partial agonist, varenicline, for smoking cessation. Arch Intern Med. Neurochemical evidence for antagonism by olanzapine of dopamine, serotonin, alpha 1-adrenergic and muscarinic receptors in vivo in rats. Antipsychotics from theory to practice: integrating clinical and basic data.

J Clin Psychiatry. The efficacy of lamotrigine in clozapine-resistant schizophrenia: a systematic review and meta-analysis. Schizophr Res. All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Services on Demand Journal. How to cite this article.

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