We'd like to understand how you use our websites in order to improve them. Register your interest. We revised clinical files of patients with brain astrocytomas treated at the Mexican National Institutes of Cancer, and Neurology and Neurosurgery. Prognostic factors, survival and disease free survival were analyzed.

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Introduction: Since the introduction of genetic and molecular criteria in the World Health Organization WHO classification of brain tumours, there has been a diagnostic reclassification between certain astrocytomas and oligodendro-gliomas with histological and genetic discordances, the prognosis of which is unknown. Aim: To analyse the implications of the diagnostic reclassification of brain gliomas according to the WHO criteria, especially depending on isocitrate dehydrogenase IDH mutation and 1p19q codeletion.

Patients and methods: We conducted a retrospective study of gliomas treated from 1 January to 31 December , with analyses of clinicoradiological aspects and prognoses, and with available and complete follow-up until 31 March Results: From a total of brain gliomas, a molecular diagnosis and a diagnostic re-evaluation were carried out in 69 cases grade II-IV astrocytomas or oligodendrogliomas.

Twenty-four reclassified gliomas were detected, usually oligodendro-gliomas that became astrocytomas, and which showed greater survival, derived from their not being classified as grade IV. The prognostic factors were: young age, focus, grade II and no contrast enhancement or necrosis, or multiplicity.

No variations were detected according to the molecular pattern with IDH mutation or codeletion. Conclusion: The changes in diagnosis after the WHO classification of present specific clinical-radiological characteristics in this series, but no greater survival, although, due to the habitual survival in these cases, they would require a longer follow-up time. This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

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Similar articles Assessment of the impact of glioma diagnostic reclassification following the new WHO classification on a series of cases. Neurocirugia Astur. Epub Oct Leu K, et al. J Neurooncol. Epub May PMID: Molecular genetics of adult grade II gliomas: towards a comprehensive tumor classification system. Figarella-Branger D, et al. Epub Aug Histomolecular classification of adult diffuse gliomas: the diagnostic value of immunohistochemical markers. Rev Neurol Paris. Epub Sep 1. PMID: Review.

Tailored therapy in diffuse gliomas: using molecular classifiers to optimize clinical management. Taylor JW, et al. Oncology Williston Park. Show more similar articles See all similar articles. Publication types English Abstract Actions. Full-text links [x] Viguera Editores, S. Copy Download.


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