COMPOSICION DEL SURFACTANTE PULMONAR PDF

The tensoactive properties as well as the Biochemical composition of the pulmonary surfactant obtained by washlung in nine mongrel dogs, before and after papain-induced panlobulillar experimental emphysema was obtained, are studied. A relationship between the two advocated theories for the production of emphysema is tried to establish: a The diminution of surface tension of pulmonary surfactant and b The abnormal intrapulmonary proteic digestion secundary to a diminution of the inhibition of the proteases liberated by the lung by various mechanisms. The results suggest that in the genesis of emphysema the increase of the intrapulmonary proteolysis, as well as the alteration of the tensoactivity of the surfactant could play an important role. Possibly the latter fact is secondary to the former one, but in a different way as it is considered at present..

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TABLA 1. Los primeros estudios se centraron principalmente en neonatos de una edad gestacional EG 4. Los neonatos con un PN 6. Los problemas de los estudios publicados son numerosos. El AT tiene la desventaja adicional de la imposibilidad de obtener datos de los neonatos no intubados con una enfermedad menos grave para establecer comparaciones. Pocos se han replicado sobre distintas cohortes. Se pudo replicar el factor de crecimiento endotelial vascular VEGF , pero con resultados variables tabla 2.

TABLA 2. TABLA 3. No existen ensayos aleatorizados controlados EAC que apoyen o se opongan a este abordaje. TABLA 4. TABLA 5. El impacto de los corticoides prenatales sobre la DBP ha sido tema de debate, ya que algunos estudios informan de un beneficio escaso o nulo.

No es sorprendente, dada la compleja naturaleza de la enfermedad fig. Se prefiere la betametasona a la dexametasona 65, Dada la compleja naturaleza de la DBP fig.

El empleo de este abordaje combinado ha obtenido resultados prometedores No se han publica-do datos seriados para los adolescentes ni los adultos. Probablemente es consecuencia de numerosos factores, como los frecuentes episodios de hipoxia, el mal crecimiento y, posiblemente, los corticoides posnatales Los neonatos de , TABLA 6. Se ha progresado, pero persisten los problemas, y es necesario seguir investigando para mejorar los resultados. Inicio Pediatrics Dificultades, problemas y progresos en la displasia broncopulmonar.

Dificultades, problemas y progresos en la displasia broncopulmonar.. Descargar PDF. Anita Bhandari a , Vineet Bhandari b. Texto completo.

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Evidence from twin study implies possible genetic susceptibility to bronchopulmonary dysplasia. Semin Perinatol, 20 , pp. Genes and environment in common neonatal lung disease. Neonatology, 91 , pp. The genetic basis for bronchopulmonary dysplasia. Front Biosci, 11 , pp. Pediatr Pulmonol, 42 , pp. Comparison of tracheal aspirate and bronchoalveolar lavage specimens from premature infants. Biol Neonate, 82 , pp. Pediatr Res, 55 , pp. Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death.

Nat Med, 12 , pp. NF-kappaB in tracheal lavage fluid from intubated premature infants: association with inflammation, oxygen, and outcome. Matrix metalloproteinases-2, -8, and -9 and TIMP-2 in tracheal aspirates from preterm infants with respiratory distress. Lower concentration of pulmonary hepatocyte growth factor is associated with more severe lung disease in preterm infants.

J Pediatr, , pp. CC chemokine concentrations increase in respiratory distress syndrome and correlate with development of bronchopulmonary dysplasia. Pediatr Pulmonol, 37 , pp. Elevation of interleukin-8 and interleukin-6 precedes the influx of neutrophils in tracheal aspirates from preterm infants who develop bronchopulmonary dysplasia.

Pediatr Pulmonol, 24 , pp. Increase in the concentration of transforming growth factor beta-1 in bronchoalveolar lavage fluid before development of chronic lung disease of prematurity. Peptide growth factors in tracheal aspirates of mechanically ventilated preterm neonates. Pediatr Res, 53 , pp. Bronchoalveolar lavage in children. European Respiratory Society. Eur Respir J, 15 , pp. Interleukin1beta in the bronchoalveolar lavage fluid of premature neonates: a marker for maternal chorioamnionitis and predictor of adverse neonatal outcome.

J Matern Fetal Neonatal Med, 14 , pp. Increased levels of tumor necrosis factor-alpha and decreased levels of interleukin p70 in tracheal aspirates, within 2 hrs after birth, are associated with mortality among ventilated preterm infants. Pediatr Crit Care Med, 6 , pp. Urinary F2-isoprostanes are poor prognostic indicators for the development of bronchopulmonary dysplasia. J Perinatol, 27 , pp. Urine bombesin-like peptide elevation precedes clinical evidence of bronchopulmonary dysplasia.

Oral mucosal microvascular abnormalities: an early marker of bronchopulmonary dysplasia. Pediatr Res, 56 , pp. Mechanical ventilation uncouples synthesis and assembly of elastin and increases apoptosis in lungs of newborn mice: prelude to defective alveolar septation during lung development?

Dysregulation of pulmonary elastin synthesis and assembly in preterm lambs with chronic lung disease. Imbalance between cysteine proteases and inhibitors in a baboon model of bronchopulmonary dysplasia. Cathepsin S deficiency confers protection from neonatal hyperoxiainduced lung injury. Hepatocyte growth factor is required for alveologenesis in the neonatal rat. Protective effect of keratinocyte growth factor against lung abnormalities associated with hyperoxia in prematurely born rats.

Biol Neonate, 83 , pp. IL-1beta disrupts postnatal lung morphogenesis in the mouse. Developmental differences in the responses of IL-6 and IL transgenic mice exposed to hyperoxia.

Antimacrophage chemokine treatment prevents neutrophil and macrophage influx in hyperoxia-exposed newborn rat lung. Conditional overexpression of bioactive transforming growth factor-beta1 in neonatal mouse lung: a new model for bronchopulmonary dysplasia? TGF-beta-neutralizing antibodies improve pulmonary alveologenesis and vasculogenesis in the injured newborn lung.

Effect of preterm birth on hypoxia-inducible factors and vascular endothelial growth factor in primate lungs. Pediatr Pulmonol, 40 , pp. J Investig Med, 53 , pp.

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Mucociliary clearance system in lung defense. Vargas M. Becario Conicyt. Becaria Conicyt.

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