Micromeritics is the science and technology of small particles and includes the study of the fundamental and derived properties of individual as well as a collection of particles. The micromeritic properties of a drug can be related in a significant way to the physical, chemical and pharmacological properties of a drug. Clinically, the particle properties can affect its release from dosage forms that are administered orally, parenterally, topically and rectally. The product quality of tablets, capsules, suspensions and emulsions from the viewpoint of both uniformity and stability depends on the micromeritic properties such as particle size, shape, surface morphology, density and flowability. The study of the fundamental and derived properties of particles has a number of applications in the field of pharmacy, including the following: Dissolution: The surface area per unit weight, which is known as the specific surface, is increased by reduction in the particle size.
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From particle structure to bulk powder properties Powders are an abundant and diverse class of products that underpin the health and comfort of day-to-day life. From the fluid catalytic cracking catalysts used for oil refining, and metal powders that make up aerospace components, to pharmaceutical formulations, cosmetics and milk powder. Developing powders fit for every purpose relies on engineering materials from the particle scale through to bulk powder performance.
Micromeritics supports such work with a uniquely complete and powerful portfolio of analytical solutions. These characterize:. Powders are usefully thought of as bulk assemblies consisting of particles, most usually air and low levels of moisture. Particle properties often define critical aspects of product performance: the dissolution rate of a drug; catalytic activity; or the surface finish delivered by an abrasive. However, particle properties also impact bulk powder behavior including flowability, compressibility, permeability and ease of fluidization.
These properties, in turn, correlate directly with product and process performance: the fluidization performance of a catalyst; tablet hardness; and the feasibility of recycling an additive manufacturing metal powder. The knowledgeable manipulation of the form and functionality of particles and powders is essential for commercial success and relies on a sound understanding of all relevant properties.
Powder behaviour cannot currently be securely predicted from particle properties. This is why the development of cost-efficient processes and products with competitive performance demands a powder characterization toolkit that extends from particle structure through to bulk powder properties. Request Quote. Pharmacopeial Convention Webinars. Particle structure via measurements of: Surface area Porosity and Density Particle morphology, via measurements of: Particle size distributions, for pure or blended materials Particle shape parameters that define form, regularity, opacity and Surface topography Bulk powder behavior, via measurements of: Dynamic flow properties Shear parameters such as unconfined yield strength Bulk powder properties including bulk density, compressibility and permeability.
Micromeritics and Powder Rheology - PowerPoint PPT Presentation
Search This Blog. Average particle size, Particle size distribution, Number and weight distribution. Methods of determining particle size : optical microscopy, sieving, sedimentation. Particle volume measurement, Particle shape, Specific surface area. Methods of determining surface area : adsorption method, air permeability method.
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