From Wikimedia Commons, the free media repository. See also category: Y-chromosomal Adam. Media in category "Mitochondrial Eve" The following 22 files are in this category, out of 22 total. African Mitochondrial descent.

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Mitochondria are commonly known as the powerhouses of cells. However, they contribute much more to cellular function than just the production of energy. Mitochondria regulate levels of calcium, an essential component of cellular communication, control programmed cell death, and even contain their own DNA.

With mitochondria responsible for a wide variety of processes and their dysfunction implicated in an ever-increasing number of disorders, understanding the mutations in both mtDNA and cellular DNA that affect mitochondrial function is essential. Cellular DNA, the genetic blueprint that codes for all the proteins in the body, is inherited from both the mother and father.

Mitochondrial DNA, however, was believed to only be passed down from the mother. The authors examined the mtDNA of a young patient suspected to have a mitochondrial disorder. Continuing this analysis in the parents of the maternal grandfather showed a similar biparental inheritance pattern.

The sequencing was repeated at two other independent labs, since contamination could have caused these unexpected results. Two other, unrelated families with high levels of variation in their mtDNA were analyzed and in these families, there is clear evidence for inheritance of mtDNA from both parents as well. The potential implications of this study are far-reaching.

Any previous DNA sequence analysis yielding similar results was commonly assumed to be due to contamination or sample mix-up. It is possible that paternal inheritance of mtDNA is more widespread than even the results of this study suggest. From a biological standpoint, the mechanism underlying this inheritance pattern is completely unknown, and could be due to mutations in mtDNA, cellular DNA, or both. In humans, paternal mitochondria are eliminated after fertilization, though it is essential that sperm cells contain mitochondria beforehand to power their motion.

It seems likely that some mutation in this process allows both the survival of paternal mitochondria and an increase in their numbers to levels comparable to the maternal population.

Finally, and perhaps most interestingly, this could potentially have pronounced implications for medicine. Preventing the inheritance of pathogenic mutations from the maternal mtDNA has been difficult, but if this paternal inheritance mechanism can be understood and employed in embryos at risk for mitochondrial disorders, it may be possible to more effectively treat some of the large number of disorders associated with mitochondrial dysfunction. Giovanni Andrea Avanzi. An alternative and mechanistically more simplistic explanation for the findings presented in Luo et al paper is presence of a Mega-NUTM.

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Notify me of new posts by email. Currently you have JavaScript disabled. In order to post comments, please make sure JavaScript and Cookies are enabled, and reload the page. Click here for instructions on how to enable JavaScript in your browser. Skip to content Mitochondria are commonly known as the powerhouses of cells. Managing Correspondent: Andrew T. Leave a Reply Cancel reply Your email address will not be published. Previous Previous post: Later school start times may help improve school performance.

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A Joint Effort: Inheritance of Mitochondrial DNA from Both Parents





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